Andrographolide | 2389

A major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo. Prevents hyperglycemia in rat diabetes model. Irreversible antagonist of NK-κB and AP-1 (IC₅₀ = 15 µM).

Andrographolide is a major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo.

2389 | Andrographolide DataSheet

Alternate Name/Synonyms:

Appearance: Off-white solid

Formulation: N/A

CAS Number: 5508-58-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₃₀O₆

Molecular Weight: 350.45

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (~25 mg/ml) or EtOH (~ 8 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A NF-kappa B activation inhibitor

MDL Number: MFCD07778082

PubChem CID: 5318517

SMILES: CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

InChi: InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChi Key: BOJKULTULYSRAS-OTESTREVSA-N