ANGPTL-3, Human Recombinant | P1283

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind alpha-5/beta-3 integrin’s leading to endothelial cell adhesion and migration. Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 62 kDa, and contains 452 amino acid residues including a C-terminal His tag.

P1283 | ANGPTL-3 Human Recombinant DataSheet

Biomolecule/Target: ANGPTL-3

Synonyms: Angiopoietin-like protein 3, ANG-5, ANGPT5, Angiopoietin-5, Angiopoietin-related protein 3, ANGPTL3

Alternates names: Angiopoietin-like protein 3, ANG-5, ANGPT5, Angiopoietin-5, Angiopoietin-related protein 3, ANGPTL3

Taglines: Inhibits lipoprotein lipase (LPL) and endothelial lipase (EL)

NCBI Gene ID #: 9255

NCBI Gene Symbol: AIMP1

Gene Source: Human

Accession #: Q12904

Recombinant: Yes

Source: CHO cells

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: 98%

Assay #2: HPLC

Endotoxin Level: <0.1 EU/g

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to induce apoptosis in MCF-7 cells using a concentration range of 20-40 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 18.3 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 10mM Sodium Phosphate, pH 7.5.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A