ANP32B Antibody (N-term) [APR04165G]

ANP32B Antibody (N-term) [APR04165G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ANP32B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ANP32B.

Cellular Localisation: [Isoform 1]: Nucleus. Cytoplasm Note=Accumulates in the nuclei at the S phase.

Molecular Weight: 28788

Clone: Polyclonal

Gene Name: ANP32B

Gene ID: 10541

Function: Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:20015864, PubMed:18039846) . Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis (PubMed:20015864) . Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes (PubMed:20538007, PubMed:18039846) . Plays also an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1 (PubMed:17178712) . Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation (By similarity) .

Summary: Tissue Location: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Acidic leucine-rich nuclear phosphoprotein 32 family member B, Acidic protein rich in leucines, Putative HLA-DR-associated protein I-2, PHAPI2, Silver-stainable protein SSP29, ANP32B, APRIL, PHAPI2