Anti- ACVRL1 Antibody | FNab00131

Anti- ACVRL1 Antibody | FNab00131 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.

Immunogen: activin A receptor type II-like 1

synonyms: Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I

Molecular weight (observed) : 56 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:200-1:1000; IHC: 1:100-1:400; IP: 1:200-1:1000

Research Area: Cardiovascular, Metabolism, Signal Transduction