Anti- AKAP10 Antibody | FNab00250

Anti- AKAP10 Antibody | FNab00250 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity) .

Immunogen: A kinase (PRKA) anchor protein 10

synonyms: AKAP10, D AKAP2, AKAP 10, PRKA10, D AKAP 2

Molecular weight (observed) : 74 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC, FC, IP

Recomended Dillution : WB: 1:500-1:5000; IHC: 1:20-200

Research Area: Signal Transduction