Anti- AKAP8L Antibody | FNab00258

Anti- AKAP8L Antibody | FNab00258 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Could play a role in constitutive transport element (CTE) -mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034) . Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601) . May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899) . May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639) . Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585) . May be involved in regulation of pre-mRNA splicing (PubMed:17594903) . (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters (PubMed:11884601) . Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses (PubMed:11402034) . In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA (Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity (PubMed:25034436) .

Immunogen: A kinase (PRKA) anchor protein 8-like

synonyms: A kinase anchor protein 8 like, AKAP8 like protein, AKAP8L, DKFZp434L0650, HA95, HAP95, Helicase A binding protein 95, Homologous to AKAP95 protein, NAKAP, NAKAP95, Neighbor of AKAP95

Molecular weight (observed) : 72 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC, IF, WB, IP

Recomended Dillution : WB: 1:200-1:2000; IF: 1:20-200

Research Area: Cell Division and Proliferation