710
Anti- ALK, CD246 Antibody | FNab00309
- SKU:
- 710-FNab00309-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- ALK, CD246 Antibody | FNab00309 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.
Immunogen: anaplastic lymphoma receptor tyrosine kinase
synonyms: ALK, ALK tyrosine kinase receptor, ALK, CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK
Molecular weight (observed) : 140-220 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience