Anti- alpha 1 Antichymotrypsin / AACT Antibody | FNab00318

Anti- alpha 1 Antichymotrypsin / AACT Antibody | FNab00318 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 8F10

Isotype: IgG2b

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Human SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a member of the serine protease inhibitor class, and is a plasma alpha globulin glycoprotein which increases in the blood during the inflammatory process. SerpinA3, is also an inhibitor of neutrophil cathepsin G, mast cell chymases and pancreatic chymotrypsin. SerpinA3 is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease. SerpinA3 has also been implicated in the pathology of a number of devastating human diseases including chronic obstructive pulmonary disease (COPD), Parkinson’s disease (PD), Alzheimer’s disease (AD), Stroke, Cystic Fibrosis, Cerebral Haemorrhage and Multiple System Atrophy.

Immunogen: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

synonyms: A1 Antichymotrypsin, AACT, ACT, Alpha 1 antichymotrypsin, GIG24, GIG25, Serpin A3, SERPINA3

Molecular weight (observed) : 60 kDa

Reactivity Species: Human

Tested Application: ELISA, IHC, WB, IF

Recomended Dillution : WB: 1:1000-1:10000; IHC: 1:20-1:300

Research Area: Cancer, Immunology, Cardiovascular, Metabolism