710
Anti- AMFR Antibody | FNab00358
- SKU:
- 710-FNab00358-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- AMFR Antibody | FNab00358 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD) . The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
Immunogen: autocrine motility factor receptor
synonyms: AMF receptor, isoform 2, AMFR, GP78, RING finger protein 45, RNF45
Molecular weight (observed) : 73 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:500-1:5000; IF: 1:10-1:100; IHC: 1:20-1:200; IP: 1:200-1:2000
Research Area: Epigenetics, Signal Transduction, Metabolism