Anti- Amphiregulin Antibody | FNab00374

Anti- Amphiregulin Antibody | FNab00374 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR) . AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs. Post-translastional modfications of 50-kDa pro-AREG produces a major soluble 43-kDa form, 28-, 26-, 16-kDa membrane anchored forms, and soluble 21-, 19-, and 9-kDa forms (PMID: 9642297) .

Immunogen: amphiregulin

synonyms: Amphiregulin, AR, AREG, AREGB, CRDGF, SDGF

Molecular weight (observed) : 43 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : WB: 1:200-1:2000; IHC: 1:50-1:500; IP: 1:1000-1:10000; IF: 1:10-1:100

Research Area: Immunology, Cardiovascular, Signal Transduction