710
Anti- ARHGEF1 Antibody | FNab10091
- SKU:
- 710-FNab10091-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- ARHGEF1 Antibody | FNab10091 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Immunogen: Rho guanine nucleotide exchange factor (GEF) 1
synonyms: ARHGEF1, GEF1, LBCL2, LSC, P115 RHOGEF, p115RhoGEF, SUB1.5, ARHG1
Molecular weight (observed) : 102-110 kDa
Reactivity Species: Human, Rat
Tested Application: ELISA, IHC
Recomended Dillution : IHC: 1:20-1:200
Research Area: Signal Transduction, Metabolism