710
Anti- ARHGEF18 Antibody | FNab00561
- SKU:
- 710-FNab00561-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- ARHGEF18 Antibody | FNab00561 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS) . Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950) .
Immunogen: rho/rac guanine nucleotide exchange factor (GEF) 18
synonyms: KIAA0521
Molecular weight (observed) : 120-130 kDa
Reactivity Species: Human, Mouse
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Signal Transduction, Metabolism