Anti-ATGL Antibody (Clone# ARC1192) | A2238

Adipose Triglyceride Lipase (ATGL) is a 54 kDa lipase that belongs to patatin-like phospholipase domain containing (PNPLA) family. It is highly expressed in white and brown adipose tissue whereas a lower expression is detected in other tissues such as the liver, skeletal muscle, lung, and heart. One of the main functions of ATGL is to catalyze the initial step of lipolysis which involves the conversion of triacylglycerol (TAG) to diacylglycerol (DAG). In immune cells (such as macrophages, neutrophils), ATGL promotes pro-inflammatory response by contributing to the production of IL-6 and arachidonic acid, which are precursors of eicosanoids. In non-immune cells (such as heart, adipose tissue, liver, skeletal muscle), it inhibits the production of proinflammatory cytokines and chemokines. ATGL is downregulated in multiple human cancers such as the pancreas, liver, and lung. Mutations in the ATGL gene are associated with neutral lipid storage disease with myopathy.

A2238 | Anti-ATGL Antibody (Clone# ARC1192) DataSheet

Antibody Target: ATGL

Target Alternative Name: ATGL, TTS2, PEDF-R, FP17548, TTS-2.2, iPLA2zeta, 1110001C14Rik, PNPLA2, EC 3.1.1.3, Desnutrin, TTS2.2, IPLA2-Zeta

Tag Line: Rabbit monoclonal antibody to detect the expression of ATGL in human, mouse, and rat samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Rat,Mouse,Human

Immunogen Sequence: Synthetic peptide derived from human ATGL

Accession #: Q96AD5

Gene ID: 57104

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH 7.3

Purification: Affinity purified

Application: Western Blotting

Positive Control:

Application And Usages: WB 1:500 - 1:2000

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE