Anti- ATR Antibody | FNab00736

Anti- ATR Antibody | FNab00736 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Immunogen: ataxia telangiectasia and Rad3 related

synonyms: ATR, FRAP related protein 1, FRP1, MEC1, SCKL, SCKL1

Molecular weight (observed) : 250-290kd

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:300-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

Research Area: Epigenetics, Metabolism, Developmental biology