Anti- beta-Catenin Antibody | FNab00882

Anti- beta-Catenin Antibody | FNab00882 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Immunogen: catenin (cadherin-associated protein), beta 1, 88kDa

synonyms: b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, β catenin, β-catenin

Molecular weight (observed) : 90 kDa

Reactivity Species: Human, Mouse, Rat, Pig

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:1000-1:4000; IP: 1:500-1:1000; IHC: 1:100-1:400; IF: 1:20-1:200

Research Area: Epigenetics, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells