710
Anti- beta-Catenin Antibody | FNab00882
- SKU:
- 710-FNab00882-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- beta-Catenin Antibody | FNab00882 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Immunogen: catenin (cadherin-associated protein), beta 1, 88kDa
synonyms: b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286, β catenin, β-catenin
Molecular weight (observed) : 90 kDa
Reactivity Species: Human, Mouse, Rat, Pig
Tested Application: ELISA, WB, IHC
Recomended Dillution : WB: 1:1000-1:4000; IP: 1:500-1:1000; IHC: 1:100-1:400; IF: 1:20-1:200
Research Area: Epigenetics, Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells