Anti-CD40L (Ruplizumab), Human IgG1 Antibody | A1094

Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralizes CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the antibody was found to have a T1/2 of 531? ±?155 hours.

A1094 | Anti-CD40L (Ruplizumab), Human IgG1 Antibody DataSheet

Antibody Target: CD40LG

Target Alternative Name: CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; CD154; tumour necrosis factor related activation protein; TRAP

Tag Line: Monoclonal antibody to detect CD40L in human samples.

Category: Immunology

Host: Recombinant

Isotype: Human IgG1, kappa

Species Reactivities: Human

Immunogen Sequence: Human CD40L

Accession #: P29965

Gene ID: 959

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: Supplied in PBS, pH 7.5

Purification: SOURCE: CHO cells

Application: Block; FC

Positive Control: N/A

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans

Handling: The antibody solution should be gently mixed before use

Western Blot Verified: Not Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified: Not Verified

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified: Not Verified

Flow Cytometry Verified: Not Verified