Anti-CD80 (Galiximab), Human IgG1, lambda Antibody | A2011

Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of co-stimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed constitutively on various subtypes of B-cell lymphomas. Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-?B pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximab affects CD28 and CD152 interactions with CD80.

A2011 | Anti-CD80 (Galiximab), Human IgG1, lambda Antibody DataSheet

Antibody Target: CD80

Target Alternative Name: B7-1; T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7

Tag Line: Recombinant monoclonal antibody manufactured using Recombinant Platform with variable regions from the therapeutic antibody IDEC-114 (Galiximab) to detect CD80 expression in humans

Category: Biosimilars

Host: Recombinant

Isotype: Human IgG1, lambda

Species Reactivities: Human

Immunogen Sequence: Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line

Accession #: P33681

Gene ID: 941

Appearance: Colorless liquid

Form: Liquid

Concentration: 1 mg/ml

Formulation: Supplied in PBS, pH 7.5

Purification: SOURCE: CHO cells

Application: Block, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting, Modulate, Flow Cytometry, ELISA

Positive Control:

Application And Usages: WB, ELISA, IP, IF, IHC, FC, Block, Modulate

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: False

Immunocytochemistry Verified: False

Immunofluorescence Verified: True

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False