26
Anti-CHI3L1 Antibody | A2254
- SKU:
- 26-A2254-100-GEN
- Availability:
- Usually shipped in 5 working days
Description
Chitinase 3-like 1 (CHI3L1, YKL-40) is a 40 kDa secreted glycoprotein that belongs to the glycoside hydrolase family 18. The protein is secreted by a variety of cells such as neutrophils, chondrocytes, macrophages, smooth muscle cells, and tumor cells. It contains a chitin-binding domain but lacks chitinase activity. The gene is located on chromosome 1q31-1q32. Genetic variations of CHI3L1 are associated with multiple inflammatory and neoplastic diseases. CHI3L1 plays a key role in protection against pathogens, inflammation, oxidant-, and antigen-induced injury responses, tissue repair. Higher levels of serum CHI3L1 are associated with poor prognosis and reduced survival in multiple cancers such as colon, gastric, breast, lung cancers, glioblastoma, sarcoma, and osteosarcoma. Increased levels of CHI3L1 are also associated with inflammatory conditions such as Crohns disease, rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD). Therefore, CHI3L1 could serve as an efficient therapeutic target for the treatment of human diseases
A2254 | Anti-CHI3L1 Antibody DataSheet
Antibody Target: CHI3L1
Target Alternative Name: GP39, ASRT7, GP-39, YK-40, YKL40, CGP-39, YKL-40, YYL-40, HC-gp39, HCGP-3P, hCGP-39
Tag Line: Rabbit polyclonal antibody to detect CHI3L1 expression in human, mouse, and rat samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Rat,Mouse,Human
Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the center region of human YKL-40
Accession #: P36222
Gene ID: 1116
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification: Affinity purified
Application: Western Blotting
Positive Control:
Application And Usages: WB 1:500 - 1:1000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
Additional Information
Size: |
100 uL |
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
12 months |