Anti- CX3CL1 Antibody | FNab02089

Anti- CX3CL1 Antibody | FNab02089 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 5D1

Isotype: IgG1

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356) . Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099) . The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350) .

Immunogen: chemokine (C-X3-C motif) ligand 1

synonyms: FKN, NTT, SCYD1

Molecular weight (observed) : 90 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:500-1:2000; IHC: 1:50-1:500

Research Area: Stem Cells, Immunology, Signal Transduction