Anti- CXADR Antibody | FNab02091

Anti- CXADR Antibody | FNab02091 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268) . Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575) .

Immunogen: coxsackie virus and adenovirus receptor

synonyms: CAR

Molecular weight (observed) : 55 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, FC

Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200

Research Area: Immunology