Anti-CXCR4 Polyclonal Antibody | A2335

CXCR4 is a receptor for the chemokine CXCL12 (SDF-1) that mediates signal transduction through the increase of intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 plays a role in regulating cell migration and binds bacterial lipopolysaccharide (LPS) to mediate an inflammatory response by the innate immune system. Along with CD4, CXCR4 acts as a coreceptor for the human immunodeficiency virus (HIV-1) to allow HIV entry into host cells. CXCR4 is also overexpressed in breast cancer cells.

A2335 | Anti-CXCR4 Polyclonal Antibody DataSheet

Antibody Target: Human CXCR4

Target Alternative Name: C-X-C Motif Chemokine Receptor 4; LESTR; Fusin; SDF-1 Receptor; CD184

Tag Line: A cell surface receptor that facilitates HIV entry into host cells

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Rat Human

Immunogen Sequence: KLH-conjugated synthetic peptide derived from human CXCR4

Accession #: P61073

Gene ID: 7852

Appearance: Liquid

Form: Rabbit polyclonal

Concentration:

Formulation: In 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide

Purification: Affinity chromatography

Application: Immunohistochemistry (IHC) Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE