Anti- CYP4F3 Antibody | FNab02173

Anti- CYP4F3 Antibody | FNab02173 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B (4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) (PubMed:11461919, PubMed:16820285) . Has a 30-fold higher Km for leukotriene-B (4) compared with CYP4F3A (PubMed:11461919) . Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:16820285) . Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:16820285) .

Immunogen: cytochrome P450, family 4, subfamily F, polypeptide 3

synonyms: LTB4H

Molecular weight (observed) : 60 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism