Anti- DACH2 Antibody | FNab02231

Anti- DACH2 Antibody | FNab02231 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity) . Probably binds to DNA via its DACHbox-N domain.

Immunogen: dachshund homolog 2 (Drosophila)

synonyms: N/A

Molecular weight (observed) : 65 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, IHC, IP, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism, Developmental biology