Anti-EGFR (Matuzumab), Human IgG1 Antibody | A1090

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

A1090 | Anti-EGFR (Matuzumab), Human IgG1 Antibody DataSheet

Antibody Target: EGFR

Target Alternative Name: Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

Tag Line: Monoclonal antibody to detect EGFR in human samples.

Category: Immunology

Host: Recombinant

Isotype: Human IgG1, kappa

Species Reactivities: Human

Immunogen Sequence: Domain III of the extracellular domain of human EGFR

Accession #: P00533

Gene ID: 1956

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: Supplied in PBS, pH 7.5

Purification: SOURCE: CHO cells

Application: Block; FC; WB

Positive Control: N/A

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans

Handling: The antibody solution should be gently mixed before use

Western Blot Verified: Not Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified: Not Verified

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified: Not Verified

Flow Cytometry Verified: Not Verified