Anti- EYA1 Antibody | FNab02913

Anti- EYA1 Antibody | FNab02913 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity) . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442) . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity) . Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity) . Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity) . Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2 (By similarity) .

Immunogen: eyes absent homolog 1 (Drosophila)

synonyms: N/A

Molecular weight (observed) : 60 kDa ;50 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, IHC, WB

Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Research Area: Neuroscience, Metabolism, Developmental biology