710
Anti- EYA2 Antibody | FNab02914
- SKU:
- 710-FNab02914-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- EYA2 Antibody | FNab02914 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380) . Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884) . Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905) .
Immunogen: eyes absent homolog 2 (Drosophila)
synonyms: EAB1
Molecular weight (observed) : 57 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC, WB, IF
Recomended Dillution : WB: 1:500-1:2000; IHC: 1:20-1:200
Research Area: Neuroscience, Metabolism, Developmental biology