Anti- FANCD2 Antibody | FNab03006

Anti- FANCD2 Antibody | FNab03006 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.The antibody recognize both un-phospho and phospho-Ser (330) of FANCD2.

Immunogen: Fanconi anemia, complementation group D2

synonyms: DKFZp762A223, FA D2, FA4, FACD, FAD, FAD2, FANCD, FANCD2, FLJ23826, Protein FACD2

Molecular weight (observed) : 150-155kd

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC

Recomended Dillution : WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:20-1:200

Research Area: Epigenetics, Metabolism