Anti- GLRB Antibody | FNab03489

Anti- GLRB Antibody | FNab03489 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346) . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357) . Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) .

Immunogen: glycine receptor, beta

synonyms: N/A

Molecular weight (observed) : 56 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:2000

Research Area: Neuroscience, Signal Transduction, Developmental biology