710
Anti-GPI Antibody | FNab10496
- SKU:
- 710-FNab10496-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti-GPI Antibody | FNab10496 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Protein A+G purification
Purity: ≥95% as determined by SDS-PAGE
Host: Mouse
Clonality: monoclonal
Clone ID: 4F11
Isotype: IgG1
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
Immunogen: Glucose-6-phosphate isomerase
synonyms: GPI, AMF, GNPI, NLK, PGI
Molecular weight (observed) : 55-64 kDa
Reactivity Species: Human
Tested Application: IHC, IF
Recomended Dillution : WB: 1:2000-1:20000; IHC: 1:200-1:1000; IF: 1:50-1:200
Research Area: N/A