50

Anti Hexanoyl-Lysine (HEL) monoclonal antibody

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SKU:
50-MHL-021P-GEN
Availability:
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NULL531.00

Description

Anti Hexanoyl-Lysine (HEL) monoclonal antibody

A new biomarker for lipid peroxidation:


Oxidative damage of lipids caused by reactive oxygen species (ROS) play an important role in some diseases, lesion of cell functions and aging. Aldehydes such as malondi-aldehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE) have been reported as one of the advanced lipid peroxidation products. But recently in the earlier stage of lipid peroxidation, 13-hydroperoxyoctadecanoic acid (13-HPODE) is found to be covalently bound to proteins1). Hexanoyl-Lysine adduct (HEL) is a novel lipid hydroperoxide-modified lysine residues. HEL is formed by oxidative modification by oxidized omega-6 fatty acids such as linoleic acid or arachidonic acid. This monoclonal antibody (clone 5H4)is spesific for proteins and peptides containing HEL. Suitable for HEL detection by immunohistochemistry and western blotting.

Specifications
Clone #: 5F12
Subclass: IgG1 kappa
Antigen: N epsilon hexanoyl-Keyhole limpet hemocyanin (HEL-KLH)
Specificity: Specific to Hexanoyl-Lys adducts.
Form: Lyophilized power. Containing 10mM PBS(pH7.4), 5% sucrose, 1% BSA and 0.05% Procline 950. 100 µg/mL of IgG.
Application: Immunohistochemistry
(Recommended antibody concentration is 2 µg/mL on paraformaldehyde fixed tissue), and ELISA
Storage: Less than -20°C
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Additional Information

Size:
20 ug of IgG/vial
Type of Marker:
Lipid oxidation
Marker:
4-HNE
Storage:
Less than -20°C for 5 years. When transport, stable at least 7 days at room temperature.
Usage:
Tissue
Application:
Immunohistochemistry and western blotting.
Remark:
Popular lipid oxidantion marker.
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Hexanoyl-Lysine (HEL) ELISA kit

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Hexanoyl-Lysine (HEL) ELISA kit Biomarker for early stage of lipid oxidation Oxidative damage of lipids caused by reactive oxygen species (ROS) play an important role in some diseases, lesion of cell...
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