Anti- HLA-G Antibody | FNab09952

Anti- HLA-G Antibody | FNab09952 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: protein A+G purified

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 3C12

Isotype: IgG1

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3) . HLA-G is a non-classical MHC class I molecule with multiple immunoregulatory properties. HLA-G exhibits a restricted pattern of expression that includes placental extravillous trophoblasts at the maternal-fetal interface, where it abolishes maternal immune cell activity against fetus and establishes immune tolerance. Aberrant expression of HLA-G has been found in a variety of human neoplastic diseases. It plays an important role in the escape of tumor cells from immunosurveillance.

Immunogen: MHC class I antigen G

synonyms: HLA 6.0, HLA G, HLA G antigen, HLAG, HLA-G, MHC class I antigen G, MHC G

Molecular weight (observed) : 38 kDa

Reactivity Species: Human

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:2000-1:10000; IHC: 1:50-1:200

Research Area: Immunology