Anti-Human CD127/IL-7RA Monoclonal Antibody (AF488 Conjugated) | DL21822F

Anti-Human CD127/IL-7RA Monoclonal Antibody (AF488 Conjugated) | DL21822F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Interleukin-7 receptor subunit alpha, IL-7RA, CDw127, CD127, IL-7Rα

Reactivity: Human

Application: FCM

Background: CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Concentration: N/A

Conjugation: AF488

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: A019D5

Isotype: Mouse IgG1, κ