Anti-Human CD16 Monoclonal Antibody (AF488 Conjugated) | DL20210F

Anti-Human CD16 Monoclonal Antibody (AF488 Conjugated) | DL20210F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Low affinity immunoglobulin gamma Fc region receptor III-A, FCGR3A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a

Reactivity: Human

Application: FCM

Background: CD16 is known as low affinity IgG receptor III (FcγRIII) . It is expressed as two distinct forms (CD16a and CD16b) . CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. CD16b (FcγRIIIB) is a 48 kD glycosylphosphatidylinositol (GPI) -anchored protein. Its extracellular domain is over 95% homologous to that of CD16a, and it is expressed specifically on neutrophils. CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC) .

Concentration: N/A

Conjugation: AF488

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: CB16

Isotype: Mouse IgG1, κ