Anti-Human Notch3 Monoclonal Antibody (PE Conjugated) | DL21926F

Anti-Human Notch3 Monoclonal Antibody (PE Conjugated) | DL21926F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: NOTCH3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain

Reactivity: Human

Application: FCM

Background: The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome.

Concentration: N/A

Conjugation: PE

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: MHN3-21

Isotype: Mouse IgG1, κ