Anti- KCNAB2 Antibody | FNab04479

Anti- KCNAB2 Antibody | FNab04479 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900) . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity) . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity) . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900) . Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900) . Modulates the functional properties of KCNA5 (By similarity) . Enhances KCNB2 channel activity (By similarity) . Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity) . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9, 10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity) .

Immunogen: potassium voltage-gated channel, shaker-related subfamily, beta member 2

synonyms: KCNA2B, KCNK2

Molecular weight (observed) : 38kd

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:500 - 1:2000

Research Area: Metabolism