Anti- KEAP1 Antibody | FNab04517

Anti- KEAP1 Antibody | FNab04517 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Protein A+G purification

Purity: ≥95% as determined by SDS-PAGE

Host: Mouse

Clonality: monoclonal

Clone ID: 9E2

Isotype: IgG2a

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Immunogen: kelch-like ECH-associated protein 1

synonyms: INRF2, KIAA0132, KLHL19

Molecular weight (observed) : 55-70 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IHC, IF, WB

Recomended Dillution : WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

Research Area: Cancer, Metabolism