Anti-LAG3 Antibody (Clone# LAG3/3261) | A2275

Lymphocyte-activation gene 3 (LAG3) is an immune checkpoint protein expressed on activated T cells, NK cells, B cells, and plasmacytoid dendritic cells. It acts as a negative regulator of T cells by suppressing their activation and inhibiting immune response. The T cell inhibition is caused by the binding of LAG3 to an antigen-presenting cell called MHC Class II. LAG3 is also involved in the maturation and activation of dendritic cells. LAG3 was found to be co-expressed with PD1 and caused T-cell exhaustion. LAG3 is highly expressed in tumor-infiltrating leukocytes (TILs) of various cancers, thereby making it a promising anti-cancer target.

A2275 | Anti-LAG3 Antibody (Clone# LAG3/3261) DataSheet

Antibody Target: LAG3

Target Alternative Name: CD223, LAG3, FDC, LAG-3

Tag Line: Mouse monoclonal antibody to detect the expression of LAG3 in human samples

Category: Primary antibody

Host: Mouse

Isotype: IgG2a, kappa

Species Reactivities: Human

Immunogen Sequence: Recombinant full-length human LAG3 protein

Accession #: P18627

Gene ID: 3902

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 10 mM PBS

Purification: Protein A/G purified

Application:

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE