Anti- LGR6 Antibody | FNab04766

Anti- LGR6 Antibody | FNab04766 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Immunogen: leucine-rich repeat-containing G protein-coupled receptor 6

synonyms: FLJ14471, GPCR, LGR6, VTS20631

Molecular weight (observed) : 104 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IHC

Recomended Dillution : WB: 1:200-1:1000; IHC: 1:20-1:200

Research Area: Signal Transduction