Anti- MAFB Antibody | FNab04930

Anti- MAFB Antibody | FNab04930 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) . Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Immunogen: v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)

synonyms: KRML

Molecular weight (observed) : 45 kDa

Reactivity Species: Human, Rat

Tested Application: ELISA, IHC, WB, IP, IF

Recomended Dillution : WB: 1:500-1:2000

Research Area: Metabolism, Developmental biology