710
Anti- MAFB Antibody | FNab04930
- SKU:
- 710-FNab04930-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- MAFB Antibody | FNab04930 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity) . Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Immunogen: v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
synonyms: KRML
Molecular weight (observed) : 45 kDa
Reactivity Species: Human, Rat
Tested Application: ELISA, IHC, WB, IP, IF
Recomended Dillution : WB: 1:500-1:2000
Research Area: Metabolism, Developmental biology