710
Anti- MMACHC Antibody | FNab05227
- SKU:
- 710-FNab05227-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- MMACHC Antibody | FNab05227 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Catalyzes the reductive dealkylation of cyanocobalamin to cob (II) alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810) . Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485) . Under anaerobic conditions cob (I) alamin is the first product; it is highly reactive and is converted to aquocob (II) alamin in the presence of oxygen (PubMed:19801555) . Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249) .
Immunogen: methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
synonyms: N/A
Molecular weight (observed) : 32 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC, IP
Recomended Dillution : WB: 1:500-1:2000
Research Area: Signal Transduction, Metabolism