Anti-Mouse CD120b Monoclonal Antibody (Biotin Conjugated) | DL20546F

Anti-Mouse CD120b Monoclonal Antibody (Biotin Conjugated) | DL20546F | Gentaur UK, US & Europe Distribution

Host: Armenian Hamster

Synonyms: Tumor necrosis factor receptor superfamily member 1B, Tnfrsf1b, Tumor necrosis factor receptor 2, TNF-R2, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b

Reactivity: Mouse

Application: FCM

Background: CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β) . In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

Concentration: 0.5 mg/mL

Conjugation: Biotin

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: TR75-54.7

Isotype: Armenian Hamster IgG