Anti-Mouse CD150 Monoclonal Antibody (APC Conjugated) | DL21949F

Anti-Mouse CD150 Monoclonal Antibody (APC Conjugated) | DL21949F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: Slam, Slamf1, CD 150, Signaling lymphocytic activation molecule

Reactivity: Mouse

Application: FCM

Background: CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies.

Concentration: N/A

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: TC15-12F12.2

Isotype: Rat IgG2a, λ