Anti-Mouse CD86 Monoclonal Antibody (Biotin Conjugated) | DL20101F

Anti-Mouse CD86 Monoclonal Antibody (Biotin Conjugated) | DL20101F | Gentaur UK, US & Europe Distribution

Host: Rat

Synonyms: T-lymphocyte activation antigen CD86, Cd86, Activation B7-2 antigen, Early T-cell costimulatory molecule 1, ETC-1

Reactivity: Mouse

Application: FCM

Background: CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4) . CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Concentration: 0.5 mg/mL

Conjugation: Biotin

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: GL-1

Isotype: Rat IgG2a, κ