Anti-Mouse FcεRIα Monoclonal Antibody (PE Conjugated) | DL22053F

Anti-Mouse FcεRIα Monoclonal Antibody (PE Conjugated) | DL22053F | Gentaur UK, US & Europe Distribution

Host: Armenian Hamster

Synonyms: High affinity immunoglobulin epsilon receptor subunit alpha, Fc-epsilon RI-alpha, FcERI, Fcer1a

Reactivity: Mouse

Application: FCM

Background: FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcεRIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit.

Concentration: N/A

Conjugation: PE

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: MAR-1

Isotype: Armenian Hamster IgG