710
Anti- MYO9B Antibody | FNab05509
- SKU:
- 710-FNab05509-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- MYO9B Antibody | FNab05509 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (PubMed:9490638) . Also acts as a GTPase activator for RHOA (PubMed:9490638, PubMed:26529257) . Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257) .
Immunogen: myosin IXB
synonyms: MYR5
Molecular weight (observed) : 230-250kd
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IHC
Recomended Dillution : WB: 1:500-1:2000; IP: 1:200-1:2000
Research Area: Signal Transduction