Anti- NAT10 Antibody | FNab05562

Anti- NAT10 Antibody | FNab05562 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167) . Catalyzes the formation of N (4) -acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity) . Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167) . Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity) . Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167) . Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003) .

Immunogen: N-acetyltransferase 10 (GCN5-related)

synonyms: ALP, KIAA1709

Molecular weight (observed) : 116 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

Research Area: Cell Division and Proliferation, Metabolism