Anti-NFKBIE Antibody | A1762

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-?B activation and during myelopoiesis. NFKBIE is able to inhibit NF-?B-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-?B transcription factor complex. The NF-?B complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.

A1762 | Anti-NFKBIE Antibody DataSheet

Antibody Target: NF-kappa-B inhibitor epsilon

Target Alternative Name: I kappa B epsilon, IKBE, IKBE, mgC72568, NF kappa B inhibitor epsilon, Slc35b2

Tag Line: Polyclonal antibody to detect NF-kappa-B inhibitor epsilon in human and mouse samples.

Category: Signal Transduction

Host: Rabbit

Isotype: IgG

Species Reactivities: Mouse, Human

Immunogen Sequence: Recombinant protein of human NFKBIE

Accession #: O00221

Gene ID: 4794

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.3 mg/ml

Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Purification: Affinity purification

Application: Immunohistochemistry (IHC), Western Blotting, ELISA

Positive Control:

Application And Usages: WB 1:200-1:1000, IHC 1:50-1:200

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: True

Immunocytochemistry Verified: True

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False