Anti-NLRP3 Antibody | A1767

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

A1767 | Anti-NLRP3 Antibody DataSheet

Antibody Target: NACHT, LRR and PYD domains-containing protein 3

Target Alternative Name: AII/AVP, FCAS, PYPAF1, NLRP3, MWS, NACHT, CIAS1, AGTAVPRL

Tag Line: Polyclonal antibody to detect NLRP3 in human samples.

Category: Signal Transduction

Host: Rabbit

Isotype: IgG

Species Reactivities: Human

Immunogen Sequence: Recombinant protein of human NLRP3

Accession #: Q96P20

Gene ID: 114548

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.1 mg/ml

Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3

Purification: Affinity purification

Application: Immunohistochemistry (IHC)

Positive Control:

Application And Usages: IHC 1:15-1:50

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: False

Immunocytochemistry Verified: False

Immunofluorescence Verified: False

Immunoprecipitation Verified: False

FACS Verified: False

ELISA Verified: False

ChIP Verified: False

Dot Blot Verified: False

Flow Cytometry Verified: False